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Phenylarthrite Vetoquinol 100 ml

Phenylarthrite Vetoquinol 100 ml
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Phenylarthrite® Inject able solution 100ml

Pharmacodynamic properties

Phenylbutazone is a nonsteroidal anti-inflammatory drug of the pyrazole family which also has analgesic and antipyretic properties. It works by inhibiting the production of prostaglandins that are involved in the production of pain, inflammation and fever.

Its main metabolite, oxyphenbutazone, has similar pharmacological properties.

Pharmacokinetic characteristics

Phenylbutazone is a molecule with lipophilic properties; its solubility in water is low. Phenylbutazone is strongly bound to plasma proteins (> 98%). The plasma half-life increases with the dose. If administration is repeated, plasma residues accumulate.

Phenylbutazone is extensively metabolised by the liver before being eliminated. The major metabolites are oxyphenbutazone, γ-hydroxyphenylbutazone and γ-hydroxyoxyphenbutazone, accounting for 25-30% of the 24-hour dose.

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